Aductos de hemoglobina y micronúcleos en trabajadores hospitalarios expuesto a óxido de etileno, Venezuela

Ethylene oxide (EO) is a genotoxic carcinogen, able to react with biological macromolecules such as hemoglobin and deoxyrebonucleic acid (DNA) to form N-(2-hydroxyethyl)valine (HEV) and 7-(2-hydroxyethyl)-guanine (7-HEG), respectively; these compounds are known as adducts. We evaluated biomarkers of...

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Main Authors: Rivero, Exila, Piñero, Sofía, González Ruiz, Soraya, Sousa, Luis de, Barrio, Emilia, Delgado, Víctor, Guevara, Harold, Carrillo Corralejo, Blanca, Rodríguez, Maritza
Format: Article
Language:Spanish
Published: Instituto de Altos Estudios en Salud Pública "Dr. Arnaldo Gabaldón" 2009
Subjects:
Óxido de etileno
toxicidad
Riesgos laborales
Factores de riesgos
Salud laboral
Ethylene oxide
toxicity
Occupational risks
Risk factors
Occupational heatlh
Online Access:https://dialnet.unirioja.es/servlet/oaiart?codigo=3194269
Source:Salud de los Trabajadores, ISSN 1315-0138, Vol. 17, Nº. 1, 2009, pags. 7-22
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Aductos de hemoglobina y micronúcleos en trabajadores hospitalarios expuesto a óxido de etileno, Venezuela
Summary: Ethylene oxide (EO) is a genotoxic carcinogen, able to react with biological macromolecules such as hemoglobin and deoxyrebonucleic acid (DNA) to form N-(2-hydroxyethyl)valine (HEV) and 7-(2-hydroxyethyl)-guanine (7-HEG), respectively; these compounds are known as adducts. We evaluated biomarkers of effect and exposure workers from the central sterilization unit of a public hospital. The purpose of this descriptive study was to evaluate 10 EO-exposed employees (GE), ranging in age from 24 to 56 years, and 9 control workers from a public university (GC) of similar age.. The mean value of N-(2-hydroxyethyl)valine (HEV)(pmol/mol globin) in the GE group was 6758.6 ± 4143.6 and 465.7 ± 484.5 in the GC group; for micronuclei (MN) in lymphocytes (MNx1000 cells), the mean value in GE was 4.8 ± 2.5 and for GC it was 0.7 ± 0.8 in GC (p< 0,0001). Thioether concentrations (mmoles SH/mol creatinine), were also significantly higher in GE (38.5 ± 22.6) than in GC (23.2±8.8) (p=0,04). Standard hematological indices (hemoglobin and hematocrit) were lower in GE than in GC (p=0.03 and 0.04, respectively). These results agreed with some prior occupational biomonitoring studies that demonstrate the importance of using biomarker batteries in the evaluation of exposure to EO.

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